Really loving the seesmic web application. The user interface is clean, can grow and so easy to use. It seems so original yet all the elememts fit with current patterns.
The top and left navigation work really well together. They are uniquely different but compliment each others roles in the app. The top has been left very simple, with only 3 buttons, 1 of which is a really intuitive refresh (ajaxy) button. The buttons are connected, and make you feel like they are tabs, which is what you achieve when clicking as they switch between 2 interfaces.
The epicentre is made up of “windows”, which can contain any kind of content, timeline, searches, #tags etc. Although I would have liked to be able to see a single users tweets, but can’t seem to do it (just found a tab called updates under the user profile area, but would like to see it in the epicenter, as then I can watch multiple users without officially following them).
The search area is great. You can have multiple search results “windows” in the epicentre. Handy for watching topics of interest.
I have found client apps are good, but become out of sync when using across work and home machines (mac at home, windows at work). I really love this interface, as it give me everything the twitter web app gives me and more.